Bone marrow (BM)-derived endothelial progenitor cells (EPC) have therapeutic potentials in promoting tissue regeneration, but how these cells are modulated in vivo has been elusive.Here, we report that RBP-J, the critical transcription factor mediating Notch signaling, modulates EPC through CXCR4.In a mouse partial hepatectomy (PHx) model, RBP-J de
The Natura 2000 network is an ambitious European project aimed at nature conservation.Nevertheless, the identification and delimitation of habitats is a complex task and simultaneously essential for correct ecosystem management.In this study we compared the current habitat delimitation and designation and the results produced by Geographic Informat
ObjectiveTo investigate the mechanisms of super-enhancer-associated LINC01485/miR-619-5p/RUNX2 signaling axis involvement in osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs).MethodsOsteogenic differentiation of hBMSCs was induced in vitro.The expression levels of LINC01485 and miR-619-5p during osteogenesis were measu
Purpose.The goal of this study was to understand the impact of COVID-19 pandemic and associated lockdown measures on the volume, rate, and type of trauma presenting to the emergency department (ED) by using trauma-initiated CT studies to capture patient data.Materials and Methods.We performed a retrospective observational study comparing patients u